Wednesday, March 04, 2015

Melatonin and Aspirin - two common, cheap drugs that together prevent cancer and protect the cardiovascular system

Melatonin, the new partner to aspirin?

Aspirin is the most common drug taken for cardioprotection, with the added benefit of anticancer properties. Yet, it causes gastric haemorrhage. An alternative, safer cardioprotective drug than aspirin is needed.

Melatonin, commonly taken to induce sleep or counter jet lag, has cerebroprotective and anticancer properties, with no reported side-effects. We hypothesise that melatonin has beneficial preventive properties for various organ diseases through mechanisms not shared by aspirin.

Melatonin is synthesised mainly in the pineal gland. Its secretion into the bloodstream is regulated by the environmental light–dark cycle via the suprachiasmatic nucleus. The initial event is that very sensitive ocular photoreceptors stimulate formation of melanopsin within the basal retinal ganglia, which, in turn, sends signals to the pineal gland, from which release of melatonin, synthesised from serotonin, is either stimulated or inhibited.

Melatonin acts by both inducing sleep and restoring the inherent sleep rhythm that is related to the rise and fall of blood melatonin concentrations. Melatonin treatment helps to restore these human circadian rhythms, resulting in better cognition and less daytime fatigue1. Experimental and clinical data have implicated melatonin in reduction of ischaemic-reperfusion injury, as originally studied in isolated rodent hearts2. If melatonin concentrations also affect the occurrence of human infarcts, then the day–night pattern of changes in melatonin blood concentrations2 becomes relevant. In patients with ST-elevation myocardial infarction, the normal pattern is reversed, with less melatonin produced at night3.

In the brain, melatonin inhibits the potentially lethal opening of the mitochondrial permeability transition pore in isolated brain mitochondria, albeit at high concentrations4.

Finally, melatonin has antidiabetic5 and not well studied anticancer properties.

Overall, the organ and vascular protective qualities of melatonin at the cost of very few or no side-effects far exceed those of aspirin, which is much more widely used for cardioprotection than melatonin is. We declare no competing interests.

Lionel Opie, Sandrine Lecour Hatter Institute for Cardiovascular Research, Cape Town, Western Cape, ZA 7925, South Africa 

The Lancet, volume 385, February 28, 2015

1 Hickie IB, Rogers NL. Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet 2011; 378: 621–31.
2 Reiter RJ, Tan DX. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc Res
2003, 58: 10–19.
3 Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia-Gonzalez, et al. Association of ischemiamodified albumin and melatonin in patients with ST-elevation myocardial infarction. Atherosclerosis 2008; 199: 73–78.
4 Andrabi SA, Sayeed I, Siemen D, et al. Direct inhibition of the mitochondrial permeability transition pore: responsible for anti-apoptotic effects of melatonin. FASEB J 2004; 18: 869–71.
5 Bazwinsky-Wutschke I, Bieseke L, Mühlbauer E, Peschke E. Influence of melatonin receptor signalling on parameters involved in blood glucose regulation. J Pineal Res 2014; 56: 82–96 .

1 comment:

Anonymous said...

We maintain extremely rigorous standards of patient safety. We believe access to essential prescription drugs should be safe, convenient, and affordable for all.

cheap drugs